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Frequency of TPMT alleles in Indian patients with acute lymphatic leukemia and effect on the dose of 6-mercaptopurine

✍ Scribed by Salamun Desire; Poonkuzhali Balasubramanian; Ashish Bajel; Biju George; Auro Viswabandya; Vikram Mathews; Alok Srivastava; Mammen Chandy


Book ID
107576957
Publisher
Springer US
Year
2009
Tongue
English
Weight
174 KB
Volume
27
Category
Article
ISSN
1357-0560

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The low frequency of defective TPMT alle
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## Abstract 6‐Mercaptopurine (6MP) is an essential anticancer drug used in the treatment of childhood acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) polymorphisms are the major determinants of interindividual differences in the severe toxicity or efficacy of 6MP. Four varia