Frequency of the common fragile site at Xq27.2 under conditions of thymidylate stress: Implications for cytogenetic diagnosis of the fragile-X syndrome

Fra(X)(q27.2), the common fragile site,

Fra(X)(q27.2), the common fragile site, observed in only one of 760 cases studied for the fragile X syndrome

✍ Jenkins, Edmund C. ;Genovese, Marilyn J. ;Duncan, Charlotte J. ;Gu, Hong ;Stark- 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 382 KB 👁 2 views

## Abstract Cell cultures from 760 whole blood, amniotic fluid, chorionic villus sample, and peripheral umbilical blood sample specimens were exposed to multiple fra(X)(q27.3) induction systems (none had aphidicolin). Fifty‐three exhibited the rare fragile site, fra(X)(q27.3) or FRAXA, none of whic