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Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma

โœ Scribed by Francesco Liotta; Mauro Gacci; Francesca Frosali; Valentina Querci; Gianni Vittori; Alberto Lapini; Veronica Santarlasci; Sergio Serni; Lorenzo Cosmi; Laura Maggi; Roberta Angeli; Benedetta Mazzinghi; Paola Romagnani; Enrico Maggi; Marco Carini; Sergio Romagnani; Francesco Annunziato


Book ID
110923076
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
485 KB
Volume
107
Category
Article
ISSN
1464-4096

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## Abstract Tyrosine kinase inhibitors (TKIs) as sorafenib are known to reduce the number of immunosuppressive regulatory T cells (Tregs) in the peripheral blood and thereby shifting the immune balance to a more stimulating setting. The effect of sorafenib on intratumoural Tregs is unclear but impo