The low frequency of defective TPMT alle
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Tugba Boyunegmez Tumer; Gulen Ulusoy; Orhan Adali; Gurses Sahin; Sevgi Gozdasogl
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Article
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2007
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John Wiley and Sons
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English
⚖ 124 KB
👁 2 views
## Abstract 6‐Mercaptopurine (6MP) is an essential anticancer drug used in the treatment of childhood acute lymphoblastic leukemia (ALL). Thiopurine methyltransferase (TPMT) polymorphisms are the major determinants of interindividual differences in the severe toxicity or efficacy of 6MP. Four varia