In the face of growing chloroquine resistance of Plasmodium falciparum, efforts to prolong the clinical usefulness of the drug have partly concentrated on its combination with potential resistance-reversing compounds. However, clinical studies on such combinations have been limited. We have compared
Frequency of blood group antigens in Nigerian children with falciparum malaria
โ Scribed by Samuel K. Martin; Louis H. Miller; C.U. Hicks; Aba David-West; C. Ugbode; Mary Deane
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 270 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0035-9203
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๐ SIMILAR VOLUMES
Chlorpheniramine (Cl'), a histamine Hi-receptor antagonist, enhances the efficacy of chloroquine (CQ) in acute uncomplicated falciparum malaria. The effects of this combination therapy on the pharmacokinetic disposition of CQ is, however, unpredictable. A standard treatment with 25 mg CQ base per kg
The absorption of intramuscular phenobarbitone 7 mg.kg-1 was studied in 11 Karen children aged between 1.7 and 11 y with severe falciparum malaria. Eight of the children were comatose. Clinical findings were compared with those in 9 further children with severe malaria of similar age range (four of
The efficacy of pyrimethamineisulfadoxine (I'S) and chloroquine plus chlorpheniramine, a histamine H1 receptor blocker which reverses chloroquine insensitivity in Plasmodium falciparum in vitro, was evaluated in 100 consecutive children with acute symptomatic uncomplicated falciparum malaria. Parasi