Frequency and impact of extracolonic findings detected at computed tomographic colonography in a symptomatic population

✍ Scribed by K. Y. Khan; T. Xiong; I. McCafferty; P. Riley; T. Ismail; R. J. Lilford; D. G. Morton

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 172 KB
• Volume: 94
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.5498

✦ Synopsis

Abstract

Background

Extracolonic findings are frequently recognized alongside colonic pathology at computed tomographic colonography (CTC). This study assessed the clinical impact of extracolonic findings in a symptomatic population at high risk of colorectal cancer.

Methods

CTC was performed in a consecutive cohort of patients assessed in a fast-track colorectal cancer clinic as being at high risk of colorectal cancer. A review of CTC findings and case notes was undertaken. Patients with extracolonic findings were followed up for at least 12 months.

Results

Thirty-one (13·8 per cent) of 225 patients investigated by CTC had colorectal cancer. Extracolonic findings were identified in 81 (53·3 per cent) of 152 patients with normal or non-neoplastic bowel findings, compared with 27 (37 per cent) of 73 patients with colorectal neoplasia (P = 0·025). Twenty-four patients (10·7 per cent) with extracolonic findings underwent further investigation or treatment. The median duration of investigation was 19·5 weeks. Seventy-five clinical events were recorded, including 14 surgical procedures.

Conclusion

A prospective cost–benefit analysis of diagnostic CTC should be performed before it is established as a first-line investigation for colonic symptoms.