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Frequency and evaluation of t(14;18) translocation in Sjögren's syndrome

✍ Scribed by I. Takács; M. Zeher; L. Urbán; M. Bachmann; G. Szegedi; I. Semsei

Publisher
Springer
Year
2000
Tongue
English
Weight
95 KB
Volume
79
Category
Article
ISSN
0939-5555

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Sjögren's syndrome: Lymphoma predisposition coupled with a reduced frequency of t(14;18) translocations in blood lymphocytes
✍ Gunnel Henriksson; Marta Brant; Zoltan Sandor; Rolf Manthorpe; Anders Bredberg 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB

Sjögren's syndrome (SS) is a systemic autoimmune disorder with a strong tumor predisposition (a 44-fold elevated incidence of non-Hodgkin's lymphoma has been reported). By polymerase chain reaction analysis of t(14;18), a key lymphomagenic event in peripheral blood lymphocytes, we found a lower freq