Frequency and allelic association of common variants in the lipoprotein lipase gene in different ethnic groups: The Wandsworth Heart and Stroke Study
✍ Scribed by Stephen Hall; Philippa J. Talmud; Derek G. Cook; Paul D. Wicks; Michael J. Rothwell; Pasquale Strazzullo; Giuseppe A. Sagnella; Francesco P. Cappuccio
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 44 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0741-0395
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✦ Synopsis
The lower serum triglyceride (Tg), higher high density cholesterol (HDL-C) levels and low coronary heart disease (CHD) mortality in black populations, contrast with that in whites. By comparison, South Asian populations display a higher mortality from CHD associated with increased Tg and low HDL-C levels. Lipoprotein lipase (LPL) plays a major role in Tg metabolism. To determine if variation in the LPL gene contributes to the differences in lipid levels, we studied the frequencies and allelic associations of five common variants in the lipoprotein lipase (LPL) gene (-93T/G, D9N, N291S, S447X, and the HinddIII RFLP in intron 8) with serum Tg and HDL-cholesterol concentrations in population samples