Freidel-crafts acylation of 1-tert-butyldimethylsilylpyrrole, a very short and simple route to 3-substituted pyrroles.

✍ Scribed by Gerhard Simchen; Michal W. Majchrzak

• Publisher: Elsevier Science
• Year: 1985
• Tongue: French
• Weight: 128 KB
• Volume: 26
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)80846-7

✦ Synopsis

I-tert-Butyldimethylsilylpyrrole undergoes Friedel-Crafts acylation almost exclusively at B-position giving after sodium fluoride supported hydrolysis the 3-pyrroloketones.