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Freeze-drying V. Freeze drying as a large-scale operation

Publisher
Elsevier Science
Year
1956
Tongue
English
Weight
126 KB
Volume
6
Category
Article
ISSN
0042-207X

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The evolution of product temperature and of residual ice content in the various vials of a batch during a freeze-drying process can be significantly affected by local conditions around each vial. In fact, vapor fluid dynamics in the drying chamber determines the local pressure that, taking into acco

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## Abstract Retaining biopharmaceutical proteins in a stable form is critical to their safety and efficacy, and is a major factor for optimizing the final product. Freeze‐dried formulations offer one route for improved stability. Currently the optimization of formulations for freeze‐drying is an em