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Freeze-Drying of Pharmaceutical Crystalline and Amorphous Solutes in Vials: Dynamic Multi-Dimensional Models of the Primary and Secondary Drying Stages and Qualitative Features of the Moving Interface

โœ Scribed by Liapis, A. I.; Bruttini, R.


Book ID
118035408
Publisher
Taylor and Francis Group
Year
1995
Tongue
English
Weight
522 KB
Volume
13
Category
Article
ISSN
0737-3937

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Modeling of the primary and secondary dr
โœ P. Sheehan; A. I. Liapis ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 510 KB

A rigorous unsteady state and spatially multidimensional model is presented and solved to describe the dynamic behavior of the primary and secondary drying stages of the lyophilization of a pharmaceutical product in vials for different operational policies. The results in this work strongly motivate