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Free radicals in myocardial injury: experimental and clinical studies

โœ Scribed by N. K. Ganguly; K. Nalini; S. Wahi; V. Dhawan; S. Meenakshi; R. N. Chakravarti

Publisher
Springer
Year
1992
Tongue
English
Weight
440 KB
Volume
111
Category
Article
ISSN
0300-8177

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โœฆ Synopsis

The exposure of cardiac cells to OFR generated artificially, showed a marked decrease (p less than 0.01) in cellular utilization of glucose along with a significant decrease in calcium uptake (p less than 0.05). We have also provided evidence for a direct relationship of neutrophil OFR production with the extent of myocardial ischemia in patients of myocardial infarction. Our data provides evidence for implication of OFR in myocardial injury and the pivotal role played by modulators like calcium, ECGF and prostaglandins in potentiating damage to the myocardium.

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