Free radical scavenging activities of differently deacetylated chitosans using an ESR spectrometer

✍ Scribed by Pyo-Jam Park; Jae-Young Je; Se-Kwon Kim

• Book ID: 104009674
• Publisher: Elsevier Science
• Year: 2004
• Tongue: English
• Weight: 183 KB
• Volume: 55
• Category: Article
• ISSN: 0144-8617
• DOI: 10.1016/j.carbpol.2003.05.002

✦ Synopsis

Three kinds of partially deacetylated hetero-chitosans (90% chitosan, 90% deacetylated chitosan; 75% chitosan, 75% deacetylated chitosan; 50% chitosan, 50% deacetylated chitosan), were prepared, and their scavenging activities were investigated against 1,1-diphenyl-2picrylhydrazyl (DPPH) radical, alkyl radical, hydroxyl radical and superoxide radical using electron spin resonance spectrometer. Five mg/ml of 90, 75 and 50% chitosan scavenged 38.72, 35.52 and 13.99% of DPPH radical, respectively. The scavenging activities of heterochitosans increased from 3 to 69.39% with increasing concentration from 1.25 to 5 mg/ml of alkyl radical. In addition, 90% chitosan with relatively high degree of deacetylation showed the highest radical scavenging effects on the hydroxyl radical and superoxide radical. These results indicate that the radical scavenging activities of hetero-chitosans depend on their degree of deacetylation and concentration.