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Free Radical Reactions of Methionine in Peptides: Mechanisms Relevant to β-Amyloid Oxidation and Alzheimer's Disease

✍ Scribed by Schöneich, Christian; Pogocki, Dariusz; Hug, Gordon L.; Bobrowski, Krzysztof


Book ID
120355324
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
701 KB
Volume
125
Category
Article
ISSN
0002-7863

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Methionine oxidation by reactive oxygen
✍ Christian Schöneich 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 357 KB

The oxidation of methionine plays an important role in vivo, during biological conditions of oxidative stress, as well as for protein stability in vitro. Depending on the nature of the oxidizing species, methionine may undergo a two-electron oxidation to methionine sulfoxide or oneelectron oxidation