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Free radical formation by ansamycin benzoquinone in human breast tumor cells: Implications for cytotoxicity and resistance

โœ Scribed by M. Nabil Benchekroun; Charles E. Myers; Birandra K. Sinha


Book ID
113386467
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
723 KB
Volume
17
Category
Article
ISSN
0891-5849

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Primary resistance to chemotherapeutic agents is a major problem in the management of advanced cancer. By using oestrogen to modulate the topoisomerase II content of T-47D human breast cancer cells, we show here that cell subpopulations resistant to the topoisomerase-ll-interactive drug VP 16 (etopo