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Framework multipoint map of the long arm of human Chromosome 4 and telomeric localization of the gene for FSHD

✍ Scribed by Barbara Weiffenbach; Rebecca G. Bagley; Kathleen Falls; JoAnn Dubois; Craig Hyser; Diane Storvick; Paul Schultz; Jerry R. Mendell; Eric C. B. Millner; Stephen J. Jacobsen; Robert C. Griggs

Publisher
Springer-Verlag
Year
1992
Tongue
English
Weight
639 KB
Volume
3
Category
Article
ISSN
0938-8990

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✦ Synopsis

Mapping the long arm of Chromosome (Chr) 4 has assumed medical relevance with the establishment of linkage of facioscapulohumeral muscular dystrophy (FSHD) to distal 4q markers. We have constructed a multipoint linkage map using DNA markers that map to the long arm of Chr 4. Segregation data were collected for 17 DNA markers on the multigenerational C E P H mapping families, and data for one marker were taken from the published C E P H database. Genotypic information for six of these markers was also collected from a set of 24 families that exhibited inheritance of F S H D . Multipoint analyses allowed us to construct a map of 12 loci, connecting two previously separate linkage groups. Significant sexspecific differences in recombination were found for some genetic intervals. Four loci from the distal region of this map showed linkage with F S H D . A map using these terminal markers gave the strongest support for F S H D in the most distal position over all other possible positions.

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