Fragmentation of Singly Charged Peptide Ions by Photodissociation at λ=157 nm

✍ Scribed by Matthew S. Thompson; Weidong Cui; James P. Reilly

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 180 KB
• Volume: 43
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.200460788

✦ Synopsis

Bond-selective chemistry has been a goal of photochemists for decades, particularly since the development and proliferation of tunable laser light sources. Nevertheless, for relatively large molecules, this goal has been elusive. Rapid intramolecular vibrational relaxation appears to redistribute energy throughout large molecules on timescales faster than dissociation so that any selectivity that may be injected by an excitation process is lost. The fragmentation of peptide ions activated by blackbody radiation, [1] IR multiphoton excitation, [2] UV laser excitation, [3][4][5] and collisions with gas-phase molecules or surfaces [6,7] involves vibrational excitation of precursor ions and consequently, production of similar types of daughter ions. The latter are primarily b-and y-type fragments as defined by the standard nomenclature shown in [*] M.