✦ LIBER ✦

Fragmentation of Bosentan ® (Ro 47-0203) in ionspray mass spectrometry after collision-induced dissociation at low energy: a case of radical fragmentation of an even-electron ion

✍ Scribed by G. Hopfgartner; W. Vetter; W. Meister; H. Ramuz

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 472 KB
Volume: 31
Category: Article
ISSN: 1076-5174
DOI: 10.1002/(sici)1096-9888(199601)31:1<69::aid-jms264>3.0.co;2-q

No coin nor oath required. For personal study only.

✦ Synopsis

For metabolic studies the fragmentation of a novel endothelin receptor antagonist, Bosentan, was investigated using ionspray tandem mass spectrometry. Bosentan belongs to the sulphonamide class and a complicated and unexpected fragmentation at low energy, involving a radical fragmentation of an even-electron ion at the sulphonamide bond, is reported.