Fragmentation and rearrangement patterns of phospho-ureas. Possible consequences for biotin activation

✍ Scribed by Hachemi Belghith; Casimir Blonski; Alain Klaébé; Jacques Périé; Jean Roussel

• Book ID: 102557031
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 438 KB
• Volume: 24
• Category: Article
• ISSN: 1076-5174
• DOI: 10.1002/oms.1210240903

✦ Synopsis

Analysis by electron impact and metastable ions (MIKE technique) of the fragmentation patterns for one acyclic

and two cyclic N-phosphorylated ureas reveals for the first case an isomerization from nitrogen to the ureido oxygen atom of the phosphoryl group and subsequent fragmentation. For the other two cases, fragments result from P--N bond breaking and ring-opening. Possible involvement in the biotin-ATP activation process is discussed.