DKP formation is a serious side reaction during the solid-phase synthesis of peptide acids containing either Pro or Gly at the C-terminus. This side reaction not only leads to a lower overall yield, but also to the presence in the reaction crude of several deletion peptides lacking the first amino a
Fragment Condensation of C-Terminal Pseudoproline Peptides without Racemization on the Solid Phase
✍ Scribed by Dr. Christian Heinlein; Dr. Daniel Varón Silva; Andrea Tröster; Jasmin Schmidt; Angelina Gross; Prof. Carlo Unverzagt
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 694 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0044-8249
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A new aminoethyl-polystyrene linker, stable at low concentrations of TFA, has been developed for the solid phase synthesis of peptide amides. The described linker is stable under conditions which remove Bu(t) protecting groups (30-50% TFA in DCM) and the desired product can be finally cleaved off th