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Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein–Carbohydrate Interaction Inhibitors

✍ Scribed by Liu, Li-Kai; Finzel, Barry C.

Book ID
124081265
Publisher
American Chemical Society
Year
2014
Tongue
English
Weight
542 KB
Volume
57
Category
Article
ISSN
0022-2623

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Fragment-Based Identification of an Indu
Fragment-Based Identification of an Inducible Binding Site on Cell Surface Receptor CD44 for the Design of Protein–Carbohydrate Interaction Inhibitors
✍ Liu, Li-Kai; Finzel, Barry C. 📂 Article 📅 2014 🏛 American Chemical Society 🌐 English ⚖ 542 KB

Selective inhibitors of hyaluronan (HA) binding to the cell surface receptor CD44 will have value as probes of CD44-mediated signaling and have potential as therapeutic agents in chronic inflammation, cardiovascular disease, and cancer. Using biophysical binding assays, fragment screening, and cryst