Fragment A-B of tetanus toxin does not block neuromuscular transmission in the goldfish
โ Scribed by J. Mellanby; M. Matsuda; N. Sugimoto; D.-L. Lei; B. Bizzini
- Book ID
- 119007972
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 324 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0041-0101
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## Abstract The nontoxic binding domain of tetanus toxin (fragment C or TTC) readily undergoes retrograde axonal transport from an intramuscular injection site. This property has led to investigation of TTC as a possible vector for delivering therapeutic proteins to motor neurons. However, the vast
Tetanus toxin (TeTx) causes sympathetic hyperactivity, a major cause of mortality in generalized tetanus, apparently by obstructing the inhibition of sympathetic preganglionic neurons (SPNs). Neuroanatomic tracing and immunohistochemistry were used to investigate whether axon terminals in the interm