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Fragile sites are preferential targets for integrations of MLV vectors in gene therapy

✍ Scribed by Bester, A C; Schwartz, M; Schmidt, M; Garrigue, A; Hacein-Bey-Abina, S; Cavazzana-Calvo, M; Ben-Porat, N; Kalle, C Von; Fischer, A; Kerem, B


Book ID
110039950
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
38 KB
Volume
14
Category
Article
ISSN
0969-7128

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## Abstract The analysis of genomic distribution of retroviral vectors is a powerful tool to monitor β€˜vector‐on‐host’ effects in gene therapy (GT) trials but also provides crucial information about β€˜host‐on‐vector’ influences based on the target cell genetic and epigenetic state. We had the unique