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Fractionated radiotherapy of rat prostatic adenocarcinoma (Dunning R3327-PAP) in nonanesthetized animals

✍ Scribed by Granfors, Torvald; Bergh, Anders; L�froth, Per-Olov; Widmark, Anders

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
254 KB
Volume
39
Category
Article
ISSN
0270-4137

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✦ Synopsis

BACKGROUND.

The dose-response effect of fractionated external beam radiotherapy on nonanesthetized rats bearing the androgen-sensitive prostatic adenocarcinoma Dunning R3327-PAP was studied. METHODS. The radiation was given with a photon beam from a 4-MeV linear accelerator in doses from 4 to 11 Gray per fraction during 5 consecutive days. When the tumors with low and intermediate radiation doses relapsed into regrowth, the rats were castrated. Tumor volumes and rat weights were followed, and at the end of the study a morphometric analysis of the tumors was done. RESULTS. Fractionated irradiation induced a dose-dependent delay in tumor growth in hormonally intact rats. Castration stopped the tumor regrowth, showing that some of the tumor cells were still hormone-sensitive. The study was facilitated by the nonanesthesia procedure. CONCLUSIONS. The Dunning R3327-PAP hormone-sensitive rat tumor is sensitive to radiotherapy in a dose-dependent way. Regrowing, irradiated tumors contain hormonesensitive cells. This work provided basic knowledge for further experimental studies of the effects of radiation on prostatic adenocarcinoma.

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