Natural products constitute a rich source of structurally diverse compounds that display exceptional biochemical and cellular activities. Although many natural products bind reversibly to their protein targets to alter protein-protein interactions and/or catalytic activity, others produce their bi
โฆ LIBER โฆ
(-)-FR182877 Is a Potent and Selective Inhibitor of Carboxylesterase-1.
โ Scribed by Gregory C. Adam; Christopher D. Vanderwal; Erik J. Sorensen; Benjamin F. Cravatt
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 61 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract __Herein, we examine the potential of a nitrileโcontaining propionic acid moiety as an electrophile for covalent attack by the activeโsite cysteine residue of caspaseโ 1. The syntheses of several cyanopropanateโcontaining small molecules based on the optimized peptidic scaffold of prodru