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FoxP3+ regulatory T cells are distinct from leukemia cells in HTLV-1–associated adult T-cell leukemia

✍ Scribed by Frederic Toulza; Kisato Nosaka; Masafumi Takiguchi; Tony Pagliuca; Hiroaki Mitsuya; Yuetsu Tanaka; Graham P. Taylor; Charles R.M. Bangham

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
395 KB
Volume
125
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Human T‐lymphotropic virus type 1 (HTLV‐1) is the causative agent of adult T‐cell leukemia/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (T~regs~) which, in common with ATLL cells, express both CD25 and FoxP3, and so contribute to the severe immune suppression typical of ATLL. We report here that the frequency of CD25^+^ cells varied independently of the frequency of FoxP3^+^ cells in both a cross‐sectional study and in a longitudinal study of 2 patients with chronic ATLL. Furthermore, the capacity of ATLL cells to suppress proliferation of heterologous CD4^+^CD25^−^ cells correlated with the frequency of CD4^+^ FoxP3^+^ cells but was independent of CD25 expression. Finally, the frequency of CD4^+^FoxP3^+^ cells was inversely correlated with the lytic activity of HTLV‐1‐specific CTLs in patients with ATLL. We conclude that ATLL is not a tumor of FoxP3^+^ regulatory T cells, and that a population of FoxP3^+^ cells distinct from ATLL cells has regulatory functions and may impair the cell‐mediated immune response to HTLV‐1 in patients with ATLL. © 2009 UICC

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