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FoxO3a Negatively Regulates Nerve Growth Factor-Induced Neuronal Differentiation Through Inhibiting the Expression of Neurochondrin in PC12 Cells

✍ Scribed by Wang, Haitao; Duan, Xiaolu; Ren, Yannan; Liu, Yizhi; Huang, Min; Liu, Peiqing; Wang, Rikang; Gao, Guoquan; Zhou, Lihua; Feng, Zhongping; Zheng, Wenhua

Book ID
118822025
Publisher
Springer
Year
2012
Tongue
English
Weight
503 KB
Volume
47
Category
Article
ISSN
0893-7648

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NRAGE is a negative regulator of nerve g
NRAGE is a negative regulator of nerve growth factor-stimulated neurite outgrowth in PC12 cells mediated through TrkA-ERK signaling
✍ Zhenhua Feng; Kaizhen Li; Mei Liu; Chuanjun Wen πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 338 KB πŸ‘ 1 views

## Abstract NRAGE, also denominated as MAGE‐D1 or Dlxin‐1, is firstly identified as a molecule interacting with NGF low affinity receptor p75NTR. It facilitates cell cycle arrest and NGF‐dependent neuronal apoptosis. Here we report that NRAGE is downregulated while p75NTR is upregulated during the