## Ponder Fanconi anemia (FA) is an autosomal recessive disorder associated with hypersensitivity to DNA cross-linking agents and bone marrow failure. At least four complementation groups have been defined, and the FA group C gene (FAC) has been cloned. We have screened 76 unrelated FA patients of
Four novel mutations of the Fanconi anemia group A gene (FAA) in Japanese patients
โ Scribed by Asako Nakamura; Shinya Matsuura; Hiroshi Tauchi; Ryoji Hanada; Hirofumi Ohashi; Tomonobu Hasegawa; Koujiro Honda; Mitsuo Masuno; Kiyoshi Imaizumi; Katsuo Sugita; Toshinori Ide; K. Komatsu
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 127 KB
- Volume
- 44
- Category
- Article
- ISSN
- 1435-232X
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Fanconi anemia (FA) is an autosomal recessive syndrome associated with hypersensitivity to DNA cross-linking agents and predisposition to neoplasia. Eight complementation groups (AH) have been described, but the only FA genes cloned so far are FAC and FAA. We have recently identified 40 different ge
Fanconi anemia (FA) is a rare autosomal recessive disorder of hematopoiesis, with at least 11 complementation groups. FANCA, a gene for group A, accounts for the majority of FA patients. Previous studies of FANCA mutations revealed high allelic heterogeneity, frequent occurrence of large deletions,
Fanconi anemia (FA) is a rare autosomal recessive disorder of hematopoiesis with eight complementation groups (FA-A, B, C, D1, D2, E, F and G). To date, seven of the FA genes have been identified. Although extensive analyses in Western countries revealed that the subgroup prevalence and mutational s
Fanconi anemia (FA), an autosomal recessive disorder characterized by a progressive pancytopenia associated with congenital anomalies and high predisposition to malignancies, is a genetically and clinically heterogeneous disease. At least eight complementation groups (FA-A to FA-H) have been identif