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Four new microginins, linear peptides from the cyanobacterium Microcystis aeruginosa

✍ Scribed by Keishi Ishida; Hisashi Matsuda; Masahiro Murakami

Book ID
104208885
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
626 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

Four new linear peptides, related to microginins 299-A (1) and 299-B (2), were isolated from the cyanobacteriurn Microcystis aeruginosa. Microginins 299-C (3) and 299-D (4), from M. aeruginosa (N'IES-299), inhibited ieucine aminopeptidase with ICs0's of 2.0 and 6.4 Itg/mL, respectively. Microginins 99-A ( 5) and 99-B ( 6), from M. aeruginosa (NIES-99), did not inhibit leucine aminopeptidase. These structures were elucidated to be 3-6 on the basis of 2D NMR data and chemical degradation.

πŸ“œ SIMILAR VOLUMES

Microginins 299-A and -B, leucine aminop
Microginins 299-A and -B, leucine aminopeptidase inhibitors from the cyanobacterium Microcystis aeruginosa (NIES-299)
✍ Keishi Ishida; Hisashi Matsuda; Masahiro Murakami; Katsumi Yamaguchi πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 399 KB

Microginins 299-A (1 and -B (2) have been iscdated from the cyanobacterium MicroQ,stis aeruginosa . Their structures were determined by tw(~-dimensional I H-iH and iH-i'~c NMR correlation experimems and confirmed by mass spectral and amino acid analyses, Their absolute stereochemistries were deduced