✦ LIBER ✦
Four New Cryptoporic Acid Derivatives from the Fruiting Bodies of Cryptoporus sinensis, and Their Inhibitory Effects on Nitric Oxide Production
✍ Scribed by Wen Wu; Feng Zhao; Rong Ding; Li Bao; Hao Gao; Jin-Cai Lu; Xin-Sheng Yao; Xiao-Qing Zhang; Hong-Wei Liu
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 241 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1612-1872
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Four new drimane‐type sesquiterpenoid ethers of isocitric acid, named cryptoporic acids J–M, were isolated from the fruiting bodies of Cryptoporus sinensis, together with six known cryptoporic acids. Their structures were elucidated on the basis of extensive spectroscopic analyses. Among them, cryptoporic acid D showed strong inhibition against nitric oxide (NO) production in macrophages with an IC~50~ of 45.8±3.6 μM, comparable to the positive control of hydrocortisone (IC~50~ of 40.6±2.5 μM).