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Four New 1,4-Benzoquinone Derivatives and One New Coumarin Isolated from Ardisia gigantifolia

✍ Scribed by Hongwei Liu; Yisong Zhao; Ruiyun Yang; Meiqing Zheng; Manyuan Wang; Xue Zhang; Feng Qiu; Hengshan Wang; Feng Zhao

Book ID
102253728
Publisher
John Wiley and Sons
Year
2010
Tongue
German
Weight
199 KB
Volume
93
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Four new 1,4‐benzoquinone derivatives, belamcandaquinones J (1), K (2), L (3), and M (4), and one new coumarin, 5, were isolated from the rhizome of Ardisia gigantifolia. Their structures were established by means of spectroscopic methods, and their cytotoxicity was tested in vitro against the cell lines PC‐3, EMT6, A549, Hela, RM‐1, and SGC7901. In comparison with cisplatin, compound 5 showed strong cytotoxicity with an IC~50~ value of <30β€…ΞΌM against the cell lines PC‐3 and A549. Compounds 1–4 showed no cytotoxicity against all cell lines.

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