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Four loops of the catalytic domain of factor VIIa mediate the effect of the first EGF-like domain substitution on factor VIIa catalytic activity

✍ Scribed by Jianping Jin; Lalith Perera; Darrel Stafford; Lee Pedersen


Book ID
115630942
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
593 KB
Volume
307
Category
Article
ISSN
0022-2836

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Coagulation factor VII bound to its cofactor tissue factor is the physiological initiator of blood coagulation. The interaction between factor VII and tissue factor involves all four of the structural modules found in factor VII, with the most significant contribution coming from the first EGF-like