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Four Cases of Follicular Lymphoma with t(14;18)(q32;q21) and t(3;4)(q27;p13) with LAZ3 (BCL6) Rearrangement

✍ Scribed by Agnès Daudignon; Hervé Bisiau; Fabienne Le Baron; Jean-Luc Laı̈; Marc Wetterwald; Sylvie Galiègue-Zouitina; Pierre Morel; Patrick Duthilleul

Book ID: 118564188
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 189 KB
Volume: 111
Category: Article
ISSN: 0165-4608
DOI: 10.1016/s0165-4608(98)00239-8

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The LAZ3(BCL6) gene on chromosome band 3q27 is nonrandomly disrupted in B-cell non-Hodgkin lymphoma (B-NHL) by chromosomal translocations clustered within a 3.3-kb MTC (major translocation cluster) located between the two first noncoding exons. These translocations generally result in the expression