Founder Effect at PGL1 in Hereditary Head and Neck Paraganglioma Families from The Netherlands

Is the c.3G>C mutation in the succinate

Is the c.3G>C mutation in the succinate dehydrogenase subunit D (SDHD) gene due to a founder effect in Chinese head and neck paraganglioma patients?

✍ Yang Zha; Xing-ming Chen; Ching-wan Lam; Soo-chin Lee; Sui-fan Tong; Zhi-qiang G 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 477 KB

## Abstract ## Objectives/Hypothesis: Three Chinese patients with head and neck paragangliomas have been reported to carry the c.3G>C mutation in the succinate dehydrogenase subunit D (__SDHD__) gene. In addition, in our hospital, two further patients were identified who have the same mutation. It