Fortschritte in der diagnostik und therapie des C-zell-karzinoms der schilddrüse

✍ Scribed by A. Frilling; P. E. Goretzki; H.-D. Röher

• Publisher: Springer
• Year: 1990
• Tongue: English
• Weight: 938 KB
• Volume: 375
• Category: Article
• ISSN: 1435-2451
• DOI: 10.1007/bf00185215

✦ Synopsis

Between 1986 and

1989

172 patients were operated on thyroid cancer. Twenty-nine (17%) of them had a medullary carcinoma. In 20 of these patients (69%) the carcinoma occurred in a sporadic and in 9 (31%) patients in a familial form. Eighteen patients (62%) had to be operated because of tumor recurrence and in 4 of them additional surgery was necessary because of distant metastases. Due to tumor recurrence 7 patients underwent multiple operations during the above period. Adequate first operation was performed only in 6 patients (33%). Based on family screening a carcinoma was diagnosed in 4 patients in its occult stage. Diagnostic methods include biochemical and imaging methods. Calcitonin is the most sensitive tumor marker. Basal and stimulated serum calcitonin analysis provides a very efficient method to detect medullary carcinoma in early tumor stage and to treat the disease curatively. DNA-analysis improves early diagnosis of persons at risk.