Forskolin and prostaglandin E2 regulate the generation of human cytolytic T lymphocytes
β Scribed by Manzoor M. Khan; Annie-Chen Tran; Karen M. Keaney
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 840 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0162-3109
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Regulation of immune cell activation in lymphocyte-bearing human tissues is a pivotal host function, and metabolites of arachidonic acid (prostaglandin E, in particular) have been reported to serve this function at non-mucosal sites. However, it is unknown whether prostaglandin E2 is immunoregulator
## Abstract These studies were designed to determine the degree of overlapping between cytolytic function and lymphokine production among peripheral blood human T lymphocytes. T8^+^ and T4^+^ cells were obtained by sorting purified T cells using the fluorescenceβactivated cell sorter (FACS) and clo