Formulation of solid products: two-component tablets with a disintegrating agent

✍ Scribed by S Hutin; P Accart; D Oulahna; JA Dodds

• Book ID: 104526741
• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 126 KB
• Volume: 52
• Category: Article
• ISSN: 0959-8103
• DOI: 10.1002/pi.1194

✦ Synopsis

Abstract

The formulation of binary tablets containing an insoluble powder and a disintegrating agent is examined from the point of view of the particle packing theory in terms of the relative size and proportion of the two components. A relationship is found between the overall porosity and the crush resistance, and between the contacts between particles and the disintegration time. Tablets made with an industrial tablet press for three different systems, caffeine–starch, cocoa–ultrafine sugar and cocoa–icing sugar, were tested for crush resistance and disintegration time. The results followed the theoretical predictions. Copyright © 2003 Society of Chemical Industry