Abstract
Sodium iodide‐123 (Na^123^I) is well known as a radioisotope that is used for studies of the thyroid and its metastases. ^123^I was produced from the reaction of 28 Mev protons with 99.99% enriched ^124^Xe by cyclotron. A home made target was installed and used for this purpose. The main part of the target contained target vessel, target windows and cooling system. In addition, some other part such as a cold finger, decay vessel, vacuum pump and four fingers were also designed and installed on the system. After bombardment, the production of ^123^I from ^123^Cs, the target was left for 6 hours and then rinsed with distilled water. A clear and colourless solution containing ^123^I was pumped to the hot cell. For adjusting the pH, sodium citrate buffer was used. The solution was added directly to the capsules which were already filled with inert powder. Each capsule contained 210 µCi Na^123^I. Quality control has shown 98% radiochemical and 99.96% radionuclide purity, with the yield of 2 mCi/µA. Quality control results had good accordance with the United States Pharmacopoeia. Copyright © 2007 John Wiley & Sons, Ltd.