Formulation of Docetaxel by folic acid-conjugated d-α-tocopheryl polyethylene glycol succinate 2000 (Vitamin E TPGS2k) micelles for targeted and synergistic chemotherapy

Doxorubicin conjugated to D-α-tocopheryl

Doxorubicin conjugated to D-α-tocopheryl polyethylene glycol succinate and folic acid as a prodrug for targeted chemotherapy

✍ Vanangamudi Anbharasi; Na Cao; Si-Shen Feng 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 825 KB

## Abstract This research developed a prodrug strategy to conjugate doxorubicin (DOX) to D‐α‐tocopheryl polyethylene glycol succinate (TPGS) and folic acid (FOL) for targeted chemotherapy to enhance the therapeutic effects and reduce the side effects of the drug. We synthesized two conjugates, TPGS