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Formulation of Controlled-Release Capsules of Biopharmaceutical Classification System I Drugs Using Niacin as a Model

✍ Scribed by Monica C. Chuong; Luca Palugan; Tiffany M. Su; Claudelle Busano; Ronald Lee; Giustino Di Pretoro; Anee Shah


Book ID
111768279
Publisher
Springer US
Year
2010
Tongue
English
Weight
655 KB
Volume
11
Category
Article
ISSN
1530-9932

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Sustained-release formulations such as hydroxypropyl methylcellulose (HPMC)based hydrophilic matrix tablets of poorly water-soluble drugs often result in incomplete release because of the poor solubility and dissolution rate of the drug in the hydrophilic matrix. Sulfobutylether-b-cyclodextrins ((SB