Formulation design, challenges, and development considerations for fixed dose combination (FDC) of oral solid dosage forms

Development of clinical dosage forms for

Development of clinical dosage forms for a poorly water-soluble drug II: Formulation and characterization of a novel solid microemulsion preconcentrate system for oral delivery of a poorly water-soluble drug

✍ Ping Li; Sara R. Hynes; Thomas F. Haefele; Madhu Pudipeddi; Alan E. Royce; Abu T 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 706 KB

The solution of a poorly water-soluble drug in a liquid lipid-surfactant mixture, which served as a microemulsion preconcentrate, was converted into a solid form by incorporating it in a solid polyethylene glycol (PEG) matrix. The solid microemulsion preconcentrates thus formed consisted of Capmul P