Formulation, characterization and optimization of Hepatitis B surface antigen (HBsAg)-loaded chitosan microspheres for oral delivery
✍ Scribed by Premaletha, K.; Licy, C.D.; Jose, Sajan; Saraladevi, A.; Shirwaikar, Annie; Shirwaikar, Arun
- Book ID
- 120991660
- Publisher
- Informa plc
- Year
- 2010
- Tongue
- English
- Weight
- 860 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1083-7450
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Microencapsulated liposome systems (MELs) were investigated as a potential immunization carrier for a recombinant 22-nm hepatitis B surface antigen (HBsAg) particle. MELs were prepared by first entrapping the HBsAg particles within liposomes composed of phosphatidylcholine:cholesterol (1:1 molar rat
## Abstract This project was aimed at illustrating the potential use of poly‐DL‐lactide–poly(ethylene glycol) (PELA) microspheres as a hepatitis B surface antigen (HBsAg) delivery system following subcutaneous (s.c.) or oral immunization over the current injection of an alum‐absorbed antigen. The a