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Formulating poly(lactide-co-glycolide) particles for plasmid DNA delivery

✍ Scribed by Aiman O. Abbas; Maureen D. Donovan; Aliasger K. Salem

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
162 KB
Volume
97
Category
Article
ISSN
0022-3549

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✦ Synopsis

Biodegradable poly(lactide-co-glycolide) (PLGA) particles have shown significant potential for sustained and targeted delivery of several pharmaceutical agents, including plasmid DNA (pDNA). Here, we survey current approaches to PLGA particle preparation for pDNA delivery and discuss recent progress on optimizing formulation development.

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