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Formula optimization based on artificial neural networks in transdermal drug delivery

✍ Scribed by Kozo Takayama; Junichi Takahara; Mikito Fujikawa; Hiroshi Ichikawa; Tsuneji Nagai

Book ID
114163739
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
481 KB
Volume
62
Category
Article
ISSN
0168-3659

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Simultaneous optimization based on artificial neural networks in ketoprofen hydrogel formula containing O-ethyl-3-butylcyclohexanol as percutaneous absorption enhancer
✍ Pao-Chu Wu; Yasuko Obata; Mikito Fujikawa; Chao Jie Li; Kimio Higashiyama; Kozo πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 301 KB

The inΒ―uence of the amounts of additives including 1-O-ethyl-3-n-butylcyclohexanol (OEBC), diisopropyl adipate (DIA), and isopropanol (IPA) on the penetration rate (R p ) of ketoprofen from hydrogels through rat skin in vivo was investigated. Skin irritation evoked by the application of hydrogels wa