Formation, synthetic utility and structure elucidation of a 2-bromomethyl 1,4-dihydropyridine
β Scribed by D. Alker; A.G. Swanson
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 219 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
The structure of the product obtained by reacting the 1,4-dihydropyridine 6 with pyridinium bromide perbromide has been confirmed by NMR spectroscopy as the I-bromomethyl derivative 7 and its reaction with a range of nucleophiles has been studied.
π SIMILAR VOLUMES
large strong-field increment for 2-CH~ was observed here, and the chemical shift for this carbon atom is 14.5 ppm, whereas it was more than 19.8 ppm in all other cases. A "~ effect" in this case is clearly observed not only for C(s ) but also for C(~) and C(6 ) (Table 3). The substantial dependence
## Abstract The tricyclic title compound, a symmetrical dispiro oxygen heterocycle, was isolated as a byproduct in the hydrogenation of furfuryl alcohol in the presence of hydrochloric acid. NMR studies and single crystal Xβray analysis have established the relative stereochemistry of the two ketal