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Formation of Quinonoid-Derived Protein Adducts in the Liver and Brain of Sprague-Dawley Rats Treated with 2,2‘,5,5‘-Tetrachlorobiphenyl

✍ Scribed by Lin, Po-Hsiung; Sangaiah, Ramiah; Ranasinghe, Asoka; Upton, Patricia B.; La, David K.; Gold, Avram; Swenberg, James A.

Book ID: 125888362
Publisher: American Chemical Society
Year: 2000
Tongue: English
Weight: 336 KB
Volume: 13
Category: Article
ISSN: 0893-228X
DOI: 10.1021/tx000030f

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## Abstract In order to cast light on carcinogen‐specific molecular mechanisms underlying experimental hepatocarcinogenesis in rats, in vivo mutagenicity and mutation spectra of known genotoxic rat hepatocarcinogens __N__‐nitrosopyrrolidine (NPYR), and 2‐amino‐3‐methylimidazo[4,5‐__f__]quinoline (I