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Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acyliminium ion cyclization: An efficient synthesis of Praziquantel

โœ Scribed by Joong Hyup Kim; Yong Sup Lee; Hokoon Park; Choong Sup Kim


Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
380 KB
Volume
54
Category
Article
ISSN
0040-4020

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โœฆ Synopsis


accomplished by the tandem amidoalkylalon and N-acyliminium ion cyclization of amido-acetals.


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Studies Toward the Total Synthesis of the Oxindole Alkaloid Gelsedine: An Efficient Allene-Terminated N-Acyliminium Ion Cyclization. -The preparation of the advanced synthetic intermediate (VII) in the projected synthesis of enantiopure ent-gelsedine is reported. The use of the inexpensive (S)-enan