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Formation of phostonic acids during the reduction of azidonucleosidephosphonic acids

✍ Scribed by Michael Morr; Christel Kakoschke; Ludger Ernst

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
204 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

Reduction of 5%-azido-3%,5%-dideoxy-3%-(phosphorylmethyl)nucleosides, either with H 2 /Pd/C or with dithiothreitol, leads to cyclic phosphonate esters (phostonic acids) in addition to the desired 5%-amino compounds. The phostonic acids are obtained as the main products when a 20-fold excess of dithiothreitol is used.

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