✦ LIBER ✦
Formation of novel tetrahydroisoquinoline retinoids by Pictet–Spengler reaction of dopamine and retinaldehyde under conditions of relevance to biological environments
✍ Scribed by Alessandro Pezzella; Giuseppe Prota
- Book ID
- 104251849
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 88 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Some constituents of vitamin A react with dopamine, under conditions of relevance for biological environments, to give tetrahydroisoquinoline retinoid derivatives. Three main products, from 13-cis retinaldehyde, were isolated in low yields and characterized. The formation of a Schiff base intermediate has been confirmed by HPLC analysis and the effect on reaction course of metal ions has been valued.