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Formation of Isomeric 3-Azabicyclo[3.3.1]nonanes in a Reaction of 1-(2-Hydroxyethoxy)-2,4-dinitrobenzene with Sodium Borohydride, Formaldehyde, and Methylamine

✍ Scribed by Yu. M. Atroshchenko; I. E. Shakhkel'dyan; O. Ya. Borbulevich; A. N. Shchukin; M. Yu. Antipin; V. N. Khrustalev


Book ID
106523641
Publisher
SP MAIK Nauka/Interperiodica
Year
2005
Tongue
English
Weight
609 KB
Volume
41
Category
Article
ISSN
1070-4280

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Reactions of 4-Oxoalkanoic Acids, 4. Syn
✍ Wedler, Christine ;Schick, Hans ;Scharfenberg-Pfeiffer, Doris ;Reck, Günter 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 432 KB

## Abstract Ethyl 4‐oxoalkanoates 1 react at ambient temperature in dry methanol in the presence of molecular sieve 3 Å in almost quantitative yield with 3‐aminopropanol and 2‐aminoethanol to form the bicyclic lactams __rac__‐2 and __rac__‐3, respectively. Surprisingly, the (±)‐5‐alkyl‐4‐oxa‐1‐azab